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Am J Translational Res 2011;3(3):259-268

Review Article
Study of vascular injuries using endothelial denudation model and the
therapeutic application of shock wave: a review

Cheuk-Kwan Sun, Pei-Lin Shao, Ching-Jen Wang, Hon-Kan Yip

Division of General Surgery, Department of Surgery; Department of Orthopedic Surgery; Division of Cardiology,
Department of Internal Medicine; Chang Gung Memorial Hospital - Kaohsiung Medical Center, Chang Gung
University School of Medicine, Kaohsiung; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical
University, Taiwan

Received March 13, 2011; accepted April 5, 2011; Epub April 8, 2011; Published May 15, 2011

Abstract: As death toll from cardiovascular diseases has reached historic heights in the developed world,
research efforts have been focused on both the understanding of disease progression and also the choice of
appropriate treatment strategies. Moreover, to facilitate research, an appropriate animal model is needed to
mimic the pathological changes and follow treatment results. This article reviewed the disease mechanisms
underlying vascular injuries and also the animal model of endothelial denudation using balloon catheter. On the
other hand, the biological effects of shock wave including angiogenesis and the suppression of inflammation
were reviewed. Its therapeutic impact on the cardiovascular system and its potential clinical application as well as
limitations were also discussed. (AJTR1103003).

Keywords: Shock wave therapy, vascular endothelial damage, cardiovascular diseases, animal model,
endothelial denudation, balloon catheter, angiogenesis, review

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Address all correspondence to:
Hon-Kan Yip, MD
Division of Cardiology, Department of Internal Medicine
Chang Gung Memorial Hospital
123, Ta Pei Road, Niao Sung Hsiang
Kaohsiung Hsien, 83301, Taiwan,
Tel: 886-7-7317123 ext. 2363  Fax: 886-7-7322402