Division of General Surgery, Department of Surgery; Department of Orthopedic Surgery; Division of Cardiology, Department of Internal Medicine; Chang Gung Memorial Hospital - Kaohsiung Medical Center, Chang Gung University School of Medicine, Kaohsiung; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan
Received March 13, 2011; accepted April 5, 2011; Epub April 8, 2011; Published May 15, 2011
Abstract: As death toll from cardiovascular diseases has reached historic heights in the developed world, research efforts have been focused on both the understanding of disease progression and also the choice of appropriate treatment strategies. Moreover, to facilitate research, an appropriate animal model is needed to mimic the pathological changes and follow treatment results. This article reviewed the disease mechanisms underlying vascular injuries and also the animal model of endothelial denudation using balloon catheter. On the other hand, the biological effects of shock wave including angiogenesis and the suppression of inflammation were reviewed. Its therapeutic impact on the cardiovascular system and its potential clinical application as well as limitations were also discussed. (AJTR1103003).
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