AJTR Copyright © 2009-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Am J Transl Res 2011;3(3):243-250

Review Article
The roles of EZH2 in cell lineage commitment

Ruey-Hwang Chou, Yung-Luen Yu, Mien-Chie Hung

Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan; Department of
Biotechnology, Asia University, Taichung 413, Taiwan; Graduate Institute of Cancer Biology, China Medical
University, Taichung 404, Taiwan; Department of Molecular and Cellular Oncology, The University of Texas MD
Anderson Cancer Center, Houston, TX 77030, USA.

Received April 9, 2011; accepted April 15, 2011; Epub April 21, 2011; Published May 15, 2011

Abstract: Enhancer of zeste homolog 2 (EZH2), a catalytic component of polycomb repressive complex 2 (PRC2),
epigenetically regulates chromatin structure and gene expressions through tri-methylation at histone H3K27 and
recruitment of DNA methyltransferases for gene silencing. Despite extensive studies of the role of EZH2 in cancer
progression and malignancy, increasing evidence also suggest that EZH2 plays a critical role in stem cells
renewal, maintenance, and differentiation into specific cell lineages. Here, we review the updated information
regarding how EZH2 contributes to stem cell maintenance, cell lineage determination, including myogenesis,
adipogenesis, osteogenesis, neurogenesis, hematopoiesis, lymphopoiesis, epidermal differentiation and
hepatogenesis, and how EZH2 is regulated by phosphorylation and microRNAs in these processes.

Keywords: EZH2, stem cells, cell lineage, differentiation

Full Text  PDF

Address all correspondence to:
Dr. Mien-Chie Hung
Department of Molecular and Cellular Oncology
The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd, Houston, Texas 77030, USA.
Tel: 713-792-3668; Fax: 713-794-3270

Dr. Yung-Luen Yu
Graduate Institute of Cancer Biology
China Medical University
Taichung 404, Taiwan.
Tel: +886-4-22052121 ext. 7933; Fax: +886-4-22333496