Review Article The roles of EZH2 in cell lineage commitment
Ruey-Hwang Chou, Yung-Luen Yu, Mien-Chie Hung
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 413, Taiwan; Graduate Institute of Cancer Biology, China Medical University, Taichung 404, Taiwan; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Received April 9, 2011; accepted April 15, 2011; Epub April 21, 2011; Published May 15, 2011
Abstract: Enhancer of zeste homolog 2 (EZH2), a catalytic component of polycomb repressive complex 2 (PRC2), epigenetically regulates chromatin structure and gene expressions through tri-methylation at histone H3K27 and recruitment of DNA methyltransferases for gene silencing. Despite extensive studies of the role of EZH2 in cancer progression and malignancy, increasing evidence also suggest that EZH2 plays a critical role in stem cells renewal, maintenance, and differentiation into specific cell lineages. Here, we review the updated information regarding how EZH2 contributes to stem cell maintenance, cell lineage determination, including myogenesis, adipogenesis, osteogenesis, neurogenesis, hematopoiesis, lymphopoiesis, epidermal differentiation and hepatogenesis, and how EZH2 is regulated by phosphorylation and microRNAs in these processes. (AJTR1104002).
Address all correspondence to: Dr. Mien-Chie Hung Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer Center 1515 Holcombe Blvd, Houston, Texas 77030, USA. Tel: 713-792-3668; Fax: 713-794-3270 E-mail: firstname.lastname@example.org;
Dr. Yung-Luen Yu Graduate Institute of Cancer Biology China Medical University Taichung 404, Taiwan. Tel: +886-4-22052121 ext. 7933; Fax: +886-4-22333496 E-mail: email@example.com.